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JNCI Journal of the National Cancer Institute 1999 91(24):2067-2068; doi:10.1093/jnci/91.24.2067
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 24, 2067-2068, December 15, 1999
© 1999 Oxford University Press


EDITORIALS

Refining Breast Cancer Risk Assessment With Molecular Markers: the Next Step?

Matthew J. Ellis, Daniel F. Hayes

Affiliation of authors: Breast Cancer Program, Lombardi Cancer Center, Georgetown University Medical Center, Washington DC.

Correspondence to: Daniel F. Hayes, M.D., Breast Cancer Program, Lombardi Cancer Center, Georgetown University Medical Center, 3970 Reservoir Rd., N.W., Washington, DC 20007 (e-mail: ellism@gunet.georgetown.edu).

It is now reasonably well established that tamoxifen reduces the incidence of new breast cancers (1). Prevention strategies are much more efficiently applied to populations most likely to develop the disease. Therefore, considerable effort has been focused on developing risk profile indices for breast cancer development (2,3). Currently available models have depended principally on clinical and morphologic criteria.

Breast epithelial hyperplasia lacking atypia (EHLA) is at the most benign end of a spectrum of breast lesions associated with a risk of developing invasive carcinoma. Although . . . [Full Text of this Article]

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