Skip Navigation

JNCI Journal of the National Cancer Institute 1999 91(23):1985-1986; doi:10.1093/jnci/91.23.1985
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Weinberg, C. R.
Right arrow Articles by Sandler, D. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weinberg, C. R.
Right arrow Articles by Sandler, D. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 91, No. 23, 1985-1986, December 1, 1999
© 1999 Oxford University Press

EDITORIALS

Gene-by-Environment Interaction for Passive Smoking and Glutathione S-Transferase M1?

Clarice R. Weinberg, Dale P. Sandler

Affiliations of authors: C. R. Weinberg (Biostatistics Branch). D. P. Sandler (Epidemiology Branch), National Institute of Environmental Health Sciences, Research Triangle Park, NC.

Correspondence to: Clarice R. Weinberg, Ph.D., Biostatistics Branch, P.O. Box 12233, Research Triangle Park, NC 27709.

In this issue of the Journal, a report by Bennett et al. (1) gives evidence for an interaction in never-smoking Missouri women between exposure to environmental tobacco smoke (ETS) and the homozygous null genotype for glutathione S-transferase (GST) M1 (GSTM1) in increasing the risk of lung cancer. Because GST enzymes act on certain carcinogenic constituents of tobacco smoke to make them excretable, the possibility that the null genotype could confer heightened susceptibility to ETS is plausible. Because 30%-50% of the population carry the null GSTM1 genotype, such an interaction could be an important contributor to lung cancer among never smokers. The finding also provides support with a physiologic rationale for the . . . [Full Text of this Article]

REFERENCES


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am J EpidemiolHome page
C. R. Weinberg and D. M. Umbach
Choosing a Retrospective Design to Assess Joint Genetic and Environmental Contributions to Risk
Am. J. Epidemiol., August 1, 2000; 152(3): 197 - 203.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
A. R. Tricker
Re: Environmental Tobacco Smoke, Genetic Susceptibility, and Risk of Lung Cancer in Never-Smoking Women
J Natl Cancer Inst, May 3, 2000; 92(9): 760 - 760.
[Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
W. P. Bennett, M. C. R. Alavanja, and C. C. Harris
RESPONSE: Re: Environmental Tobacco Smoke, Genetic Susceptibility, and Risk of Lung Cancer in Never-Smoking Women
J Natl Cancer Inst, May 3, 2000; 92(9): 760a - 761a.
[Full Text] [PDF]