Skip Navigation

JNCI Journal of the National Cancer Institute 1999 91(23):1979; doi:10.1093/jnci/91.23.1979
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Search for Related Content
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 91, No. 23, 1979, December 1, 1999
© 1999 Oxford University Press

IN THIS ISSUE

"Suicide" Cells as Vaccines

Can dying cells from a patient's tumor serve as an anticancer vaccine? To explore this possibility, Pierrefite-Carle et al. (p. 2014) created "suicide" tumor cells by introducing the Escherichia coli cytosine deaminase gene into cells of a rat colon carcinoma cell line. Exposure of the modified cells to the nontoxic compound 5-fluorocytosine causes them to die because the bacterial gene product converts it into the cytotoxic agent 5-fluorouracil. When the modified cells are injected into the livers of syngeneic animals, they form single experimental "suicide tumors." As expected, when animals bearing suicide tumors were treated with . . . [Full Text of this Article]

Danger to Nonsmokers

Mercaptopurine Therapy Intolerance

Missed by Mammography?

Early Detection of Renal Cancer


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?