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JNCI Journal of the National Cancer Institute 1999 91(21):1800-1801; doi:10.1093/jnci/91.21.1800
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 21, 1800-1801, November 3, 1999
© 1999 Oxford University Press

NEWS

Postmastectomy Radiation: Back to Center Stage?

Caroline McNeil

Consider the ups and downs of postmastectomy radiation. It starred in one of the first randomized clinical trials in the 1940s, which compared it to no postsurgical treatment for breast cancer and found an improvement in local and regional control of the disease. Confirmed in that role by numerous other studies, it held the status of standard treatment for several decades.

Then in the 1980s, the pendulum began to swing away from radiation after mastectomy. One problem was that it did not seem to affect survival. Another was growing evidence that radiation to the left side of the chest damaged the heart, erasing any survival advantage that may have existed. Third, and perhaps most important, the systemic approach . . . [Full Text of this Article]

Crux of Debate

Not so Easy


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