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JNCI Journal of the National Cancer Institute 1999 91(21):1796-1799; doi:10.1093/jnci/91.21.1796
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 21, 1796-1799, November 3, 1999
© 1999 Oxford University Press

EDITORIALS

Clones and Subclones in the Lung Cancer Field

Walter N. Hittelman

Correspondence to: Walter N. Hittelman, Ph.D., Department of Clinical Investigation, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030 (e-mail: Hittelman/MDACC@MDACC).

Based on a variety of clinical (1,2), histologic (3,4), cytogenetic (5-7), and molecular (8-10) data, lung cancer, like many other epithelial cancers, is suggested to develop as a multistep tumorigenesis process in a field of cancerization (11,12). Carcinogen exposure (e.g., tobacco) is believed to induce genetic damage in target cells that accumulates over years of exposure. Moreover, chronic tissue injury leads to chronic wound healing, whereby cells carrying genetic alterations that are important for survival and preferential regrowth expand at the expense of their neighbors. These surviving colonies continue to accumulate new tissue-relevant genetic alterations and eventually evolve into an invasive lesion. Since the whole aerodigestive tract is similarly exposed to carcinogen, one might predict that such clonal outgrowths develop throughout the exposed tissue.

Until recently, characterization of the fine . . . [Full Text of this Article]

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