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JNCI Journal of the National Cancer Institute 1999 91(2):111; doi:10.1093/jnci/91.2.111
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 2, 111, January 20, 1999
© 1999 Oxford University Press

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How Should HER2 Status Be Determined?

Caroline McNeil

Testing for HER2/erbB-2 is a new and unsettled territory. In general, the two principal methods are immunohistochemistry — the use of antibodies to detect overexpression of the protein — and fluorescent in situ hybridization (FISH), which detects amplification of the gene. Each has . . . [Full Text of this Article]


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