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JNCI Journal of the National Cancer Institute 1999 91(19):1608-1610; doi:10.1093/jnci/91.19.1608
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 19, 1608-1610, October 6, 1999
© 1999 Oxford University Press

NEWS

A Natural Edge: Nature Still Offers The Greatest Drug Diversity

Tom Reynolds

Today's drug developers use powerful, computer-driven techniques to churn out new molecular structures by the millions. But many scientists in the field say nature still offers the best foundation blocks for building truly novel, biologically active agents.

Some pharmaceutical companies have eliminated or cut back their natural products programs. Instead, they are betting on combinatorial chemistry, a method that emerged in the past decade and uses mathematical algorithms to generate countless variations on a single template molecule. The rapid assays used by drug makers demand a steady diet of new compounds to run through the screening mill. And combinatorial chemistry is the quickest way to make them.

Work on natural products, by contrast, moves at a . . . [Full Text of this Article]

Unique Molecules

The "Right Stuff"

Untapped Wealth


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