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JNCI Journal of the National Cancer Institute 1999 91(18):1532-1534; doi:10.1093/jnci/91.18.1532
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 18, 1532-1534, September 15, 1999
© 1999 Oxford University Press

NEWS

Pancreatic Cancer Research: Putting All Their Ducts in a Row

Bob Kuska

In the 1980s, many cancer researchers took what seemed like a logical leap of faith: If several genes must be mutated over time to create a tumor cell, it must follow that the first gene to be mutated acts as the initial flashpoint in starting a tumor. Find the flashpoint; pinpoint the cause of the tumor.

But, what if tumor cells in some parts of the body do not have a single flashpoint? What if they have multiple flashpoints that erupt over time into raging tumors that are highly metastatic, largely resistant to chemotherapy, and extremely deadly?

That is the scenario that now faces molecular biologists and geneticists who study pancreatic adenocarcinoma, which accounts for about 90% of cancer in the pancreas. After an intensive, decade-long search to locate a tumor-initiating gene, many scientists say they now have doubts that such a thing exists. With this doubt has come the . . . [Full Text of this Article]

Empty Cupboard

Working Model

No "Gatekeeper"

Chess Match


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