Skip Navigation

JNCI Journal of the National Cancer Institute 1999 91(18):1528-1529; doi:10.1093/jnci/91.18.1528
© 1999 by Oxford University Press
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Kaye, F. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaye, F. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of the National Cancer Institute, Vol. 91, No. 18, 1528-1529, September 15, 1999
© 1999 Oxford University Press

EDITORIALS

Closing in on Another Renal Cancer Suppressor Locus Near Chromosome 3p14

Frederic J. Kaye

Affiliation of author: Medicine Branch, Division of Clinical Science, National Cancer Institute, and National Naval Medical Center, Bethesda, MD.

Correspondence to: Frederic J. Kaye, M.D., National Institutes of Health, Bldg. 8, Rm. 5101, National Naval Medical Center, Bethesda, MD 20889.

A powerful method to isolate candidate tumor suppressor genes begins with genetic linkage analysis in multigenerational cancer families and requires the collection of DNA samples from affected and unaffected family members. An implicit advantage of studying familial susceptibility to disease is the guarantee that, given sufficient perseverance and luck, a susceptibility locus will ultimately be identified. Such was the case in 1993 with the isolation of the von Hippel-Lindau (VHL) gene at chromosome 3p25 (1) and in 1997 with the identification of alterations within the Met gene in hereditary papillary renal carcinoma (2,3).

In the case of the VHL gene, this work culminated several years of intense research efforts on families who are characterized by a . . . [Full Text of this Article]

REFERENCES


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?