© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 17, 1453-1458,
September 1, 1999
© 1999 Oxford University Press
COMMENTARY |
Perspective on Kaposi's Sarcoma: Facts, Concepts, and Conjectures
Affiliations of authors: M. S. Reitz, Jr., R. C. Gallo, Institute of Human Virology, University of Maryland at Baltimore; L. S. Nerurkar, International Cancer Information Center, National Cancer Institute, Bethesda, MD.
Correspondence to: Robert C. Gallo, M.D., Institute of Human Virology, University of Maryland at Baltimore, 725 W. Lombard St., Rm. S307, Baltimore, MD 21201-1192 (e-mail: coleman@umbi.umd.edu).
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INTRODUCTION |
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Kaposi's sarcoma (KS) is the most common tumor associated with human immunodeficiency virus type 1 (HIV-1) infection, occurring in approximately 30% of HIV-1-infected homosexual men. The incidence of KS has increased in this risk group by more than 100 000-fold relative to the general population (1,2). However, KS is also increased in nonhomosexual HIV-infected males by about 10 000-fold (2,3). In the absence of HIV-1 infection, KS occurs very rarely in three distinct epidemiologic forms: 1) the classic form (disease seen in older men from certain ethnic groups) (4,5), 2) the endemic form (prevalent in some parts of equatorial Africa) (5,6), and 3) a form associated with renal transplant patients (7,8). It has not been clear whether all four forms of KS represent the same disease, or, like leukemias, lymphomas,
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KS Cell Types |
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Production of Growth Factors by KS Cells |
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Role of HIV-1 Tat |
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Presence of Tat in KS Cells |
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Role of HIV-1 |
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KS and Malignancy |
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Human Herpesvirus 8 |
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NOTES |
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REFERENCES |
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