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JNCI Journal of the National Cancer Institute 1999 91(17):1445-1447; doi:10.1093/jnci/91.17.1445
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 17, 1445-1447, September 1, 1999
© 1999 Oxford University Press

NEWS

New Estrogen Receptor Adds Complexity, Recasts Drug Strategies

Tom Reynolds

Researchers studying estrogen signaling were thrown a curve ball in 1993 when mice with knocked-out estrogen receptor genes failed to display the severe deficits expected in estrogen-dependent cardiovascular and bone functions.

Subsequent studies have cleared up some of the resulting questions, while raising other questions and new therapeutic possibilities as well.

The knockout mice were sterile, with abnormal reproductive organs and bone growth. But even their survival was something of a surprise, suggesting the existence of another estrogen receptor. A report on a human knockout — a man with a mutated ER gene — described similar findings. The patient was normal in most respects but had incomplete closure of bone ends, which contributed to his 6-foot-8-inch height.

In . . . [Full Text of this Article]

Daring Hypothesis

Superior SERMS


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