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JNCI Journal of the National Cancer Institute 1999 91(17):1442-1443; doi:10.1093/jnci/91.17.1442
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 17, 1442-1443, September 1, 1999
© 1999 Oxford University Press

EDITORIALS

Bad News/Good News: Information About Breast Cancer Risk Following Prophylactic Oophorectomy

Kathy J. Helzlsouer

Correspondence to: Kathy J. Helzlsouer, M.D., M.H.S., Department of Epidemiology, The Johns Hopkins School of Hygiene and Public Health, 615 N. Wolfe St., Baltimore, MD 21205.

The ability to test for mutations in BRCA1 and BRCA2 genes and to identify women at high risk for breast cancer came before knowing what to do to effectively reduce the associated cancer risks. BRCA1 was cloned in the fall of 1994 (1), and BRCA2 was cloned in December 1995 (2). Genetic testing for mutations in these two genes came quickly after their discovery. Here we are in 1999 with only preliminary data on how effective the management options are for women who carry mutations and are thus at high risk for breast cancer.

What is it like for women who are members of these families with inherited cancer syndromes? Women see close family members develop cancer, suffer through the treatments, and often die prematurely of their disease. A . . . [Full Text of this Article]

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