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JNCI Journal of the National Cancer Institute 1999 91(17):1440-1441; doi:10.1093/jnci/91.17.1440
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 17, 1440-1441, September 1, 1999
© 1999 Oxford University Press

EDITORIALS

Human Herpesvirus 8 and Cancer

Valerie Beral, Robert Newton, Freddy Sitas

Affiliations of authors: V. Beral, R. Newton, Cancer Epidemiology Unit, University of Oxford, Imperial Cancer Research Fund, Oxford, U.K.; F. Sitas, Cancer Epidemiology Unit, National Cancer Registry, South African Institute for Medical Research, Johannesburg.

Correspondence to: Valerie Beral, M.D., Cancer Epidemiology Unit, University of Oxford, Imperial Cancer Research Fund, Gibson Bldg., The Radcliffe Infirmary, Oxford OX2 6HE, U.K.

In 1994, Chang, Moore, and colleagues (1) reported that they had discovered DNA sequences of a new herpesvirus in Kaposi's sarcoma tumor tissue. The new virus, known as Kaposi's sarcoma herpesvirus or human herpesvirus 8 (HHV8), is now widely believed to be a necessary cause of Kaposi's sarcoma [(2); reviewed in (3)]. The prevalence of antibodies against HHV8 varies substantially across populations, and there is a close association worldwide between seroprevalence rates of anti-HHV8 antibodies and the incidence of Kaposi's sarcoma. Kaposi's sarcoma is extremely rare in . . . [Full Text of this Article]

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