© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 16, 1351-1353,
August 18, 1999
© 1999 Oxford University Press
EDITORIALS |
What Defines a Useful Marker of Metastasis in Human Cancer?
Affiliations of authors: D. R. Welch, Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, Hershey; C. W. Rinker-Schaeffer, Section of Urology, Prostate Cancer Program, The University of Chicago, IL.
Correspondence to: Danny R. Welch, Ph.D., Jake Gittlen Cancer Research Institute, The Pennsylvania State University College of Medicine, 500 University Dr., Hershey, PA 17033-2390.
In this issue of the Journal, O'Connell et al. (1) describe the identification of a region on the long arm of chromosome 14 that is apparently involved in the progression of breast cancer toward metastasis. Measuring loss of heterozygosity, the investigators found that the majority of lymph node-negative breast tumors did not amplify a region linked to D14S62 and D14S51, while lymph node-positive breast tumors retained heterozygosity for these same markers. These data could imply the existence of a metastasis-promoting gene. Alternatively, the observed molecular changes may be a marker of metastatic propensity.
Since metastasis is the most lethal attribute of a cancer, it is critical that tumors be diagnosed
while still localized to achieve the highest probability of long-term survival and quality of life. In
the absence of objective evidence that metastases do not exist, earlier diagnosis would accomplish
three things: 1) increase the probability of diagnosis
NOTES
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