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JNCI Journal of the National Cancer Institute 1999 91(16):1349-1350; doi:10.1093/jnci/91.16.1349
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 16, 1349-1350, August 18, 1999
© 1999 Oxford University Press

EDITORIALS

Breast Cancer: a New Epstein-Barr Virus-Associated Disease?

Ian Magrath, Kishor Bhatia

Affiliation of authors: Division of Clinical Sciences, National Cancer Institute, Bethesda, MD.

Correspondence to: Ian Magrath, M.D., National Institutes of Health, Bldg. 10, Rm. 13N240, Bethesda, MD 20892-1928.

Epstein-Barr virus (EBV) has learned, remarkably successfully, to live with its human host. However, this ability was not acquired overnight. Closely related viruses infect old-world primates, including our closest relatives, the gorilla and chimpanzee (1), suggesting that EBV, or its immediate ancestors, has been with us since long before we were human. This association over millions of years has led to such intimacy that at least 90% of the world's adult population, including people in the most remote corners of the world, are infected by the virus, the vast majority with no serious consequences. Even infectious mononucleosis, a largely benign illness that frequently accompanies primary infection in adolescence or early adulthood, is likely to have been rare until well into the industrial era, since clinically silent infection with EBV in infancy is the norm in developing countries. However, even the best . . . [Full Text of this Article]

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