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JNCI Journal of the National Cancer Institute 1999 91(14):1180-1181; doi:10.1093/jnci/91.14.1180
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 14, 1180-1181, July 21, 1999
© 1999 Oxford University Press

EDITORIALS

Zn2+ Fingers and Cervical Cancer

Scott A. Foster, William C. Phelps

Affiliation of authors: Department of Virology, GlaxoWellcome Co., Research Triangle Park, NC.

Correspondence to: William C. Phelps, Ph.D., Department of Virology, GlaxoWellcome Co., Bldg. RC2, Rm. 3521, Research Triangle Park, NC 27709 (e-mail: wcp41432@glaxowellcome.com).

Cervical cancer will kill several hundred thousand women around the world during the next year. It ranks second only to breast cancer as the leading cause of cancer death in women worldwide (1).

The widespread use of the Papanicolaou (Pap) smear since its introduction in the 1940s as a cancer-screening tool has dramatically reduced the incidence of cervical cancer and has undoubtedly prevented the deaths of thousands of women in developed nations. Management of cervical cancer has focused on prevention through early detection and ablation of dysplastic tissues. Carcinoma in situ and invasive cancers, when diagnosed, are treated more aggressively with surgery, radiation therapy, and chemotherapy as the standard therapeutic options. Unfortunately, the standard therapies are not highly specific. In the article by Beerheide et al. (2) in this issue of the Journal, an alternative therapeutic strategy is . . . [Full Text of this Article]

ANTIVIRAL CHEMOTHERAPY FOR CANCER

E6 BIOCHEMISTRY

ZN2+ FINGERS AS TARGETS

SPECIFICITY

REFERENCES


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