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JNCI Journal of the National Cancer Institute 1999 91(14):1177; doi:10.1093/jnci/91.14.1177
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 14, 1177, July 21, 1999
© 1999 Oxford University Press

IN THIS ISSUE

Antioxidants and Prostate Cancer

Antioxidants show promise for reducing prostate cancer risk. To understand the mechanism of this protection, Ripple et al. (p. 1227) studied the effect of antioxidants vitamins C and E on several male hormone (androgen)-induced changes in a human prostate carcinoma cell line. Androgens increased both reactive oxygen species levels and the DNA-binding activity of transcriptional activators AP-1 and NF-{kappa}B, which are sensitive to oxidative stress. These effects were blocked by the antioxidants. The authors note that further studies are needed to understand the pathways involving androgens, . . . [Full Text of this Article]

Enhancing Antifolate Sensitivity

Identifying Drugs Against Human Papillomavirus

Tobacco Smoke and Lung Cancer

Colorectal Cancer in Hong Kong

BRCA1 and BRCA2 Mutations


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