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JNCI Journal of the National Cancer Institute 1999 91(13):1093; doi:10.1093/jnci/91.13.1093
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 13, 1093, July 7, 1999
© 1999 Oxford University Press

IN THIS ISSUE

Inherited Susceptibility to DNA Damage?

Studies indicate that sensitivity to mutagens is increased in patients with environmentally related cancers. This sensitivity can be evaluated by treating an individual's lymphocytes in culture with bleomycin and counting the resulting number of chromatid breaks. In combination with exposure to carcinogenic assaults, this sensitivity greatly influences cancer risk assessment, suggesting that it is a cancer susceptibility factor. Cloos et al. (p. 1125) studied the heritability of the susceptibility to DNA damage by evaluating chromatid breaks in the following three groups: 1) family members (siblings . . . [Full Text of this Article]

4-HPR and Neuroblastoma Cells

Hormone Replacement Therapy and Endometrial Cancer

Abdominal Obesity and Risk of Colorectal Cancer

A Prognostic Marker in Hepatocellular Carcinoma


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