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JNCI Journal of the National Cancer Institute 1999 91(11):906-908; doi:10.1093/jnci/91.11.906
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 11, 906-908, June 2, 1999
© 1999 Oxford University Press

NEWS

Hepatitis C Vaccine Hampered by Viral Complexity, Many Technical Restraints

Judith Randal

Singly and together hepatitis B and C viruses are the leading cause of cirrhosis of the liver and hepatocellular carcinoma, the most common form of primary liver cancer by far. But while a vaccine against the widespread hepatitis B virus became available as early as 1982, one against hepatitis C — also bloodborne, equally commonplace, and frequently chronic — has proven far more elusive.

And the prospects for an HCV vaccine are not immediate. Despite being distantly related to the yellow fever virus for which there is a vaccine, says Robert Purcell, M.D., who heads viral hepatitis research at the National Institute of Allergy and Infectious Diseases, "it [HCV] shares with the Human Immunodeficiency Virus an extreme genetic heterogeneity, including hypervariable regions. Patients tend to harbor a mix of genomes and . . . [Full Text of this Article]

Scant Research

Treatment Barriers


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