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JNCI Journal of the National Cancer Institute 1999 91(11):904-905; doi:10.1093/jnci/91.11.904
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 11, 904-905, June 2, 1999
© 1999 Oxford University Press

EDITORIALS

BRCA1 and BRCA2: a Small Part of the Puzzle

Wylie Burke, Nancy Press, Linda Pinsky

Affiliations of authors: W. Burke, Department of Medicine, University of Washington, Seattle, and Fred Hutchinson Cancer Research Center, Seattle; N. Press, Department of Public Health and Preventive Medicine, Oregon Health Sciences University, Portland; L. Pinsky, Department of Medicine, University of Washington.

Correspondence to: Wylie Burke, M.D., Ph.D., Department of Medicine, Box 354765, University of Washington, 4245 Roosevelt Way, N.E., Seattle, WA 98105 (e-mail: wburke@u.washington.edu).

The article by Peto et al. (1) in this issue of the Journal reports a low prevalence of BRCA1 and BRCA2 gene mutations among women with early-onset breast cancer. It also provides new information about the complexity of breast cancer genetics: The study results indicate that increased cancer risk among relatives of affected women is only rarely attributable to BRCA1 and BRCA2 mutations and often subject to the modifying effect of other factors.

Among women with breast cancer diagnosed before age 36 years, the study found that only 5.9% carried an identifiable BRCA1 or BRCA2 mutation. The percentage . . . [Full Text of this Article]

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