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JNCI Journal of the National Cancer Institute 1999 91(11):903-904; doi:10.1093/jnci/91.11.903
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 11, 903-904, June 2, 1999
© 1999 Oxford University Press

EDITORIALS

Taxing the Cellular Capacity for Repair: Human T-Cell Leukemia Virus Type 1, DNA Damage, and Adult T-Cell Leukemia

Karen V. Kibler, Kuan-Teh Jeang

Affiliation of authors: Laboratory of Molecular Microbiology,National Institute of Allergy and Infectious Diseases, Bethesda, MD.

Correspondence to: Kuan-Teh Jeang, M.D., PhD., National Institutes of Health, Bldg. 4, Rm. 306, Bethesda, MD 20892 (e-mail: kj7e@nih.gov).

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent for adult T-cell leukemia (ATL). In vivo, nuclei of ATL cells are morphologically altered [reviewed in (1)] and karyotypically abnormal [reviewed in (2)] with frequent trisomies (e.g., chromosomes 3 and 7). Lymphocytes infected ex vivo with HTLV-1 also show chromosomal changes (3). Collectively, these findings suggest that a loss in the ability of the . . . [Full Text of this Article]

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