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JNCI Journal of the National Cancer Institute 1999 91(11):899; doi:10.1093/jnci/91.11.899
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 11, 899, June 2, 1999
© 1999 Oxford University Press


IN THIS ISSUE

Significant Tax Consequences

Human T-cell leukemia virus (HTLV) and bovine leukemia virus (BLV) are retroviruses that cause hematopoietic cancers and encode a unique protein, Tax, which is involved in the transformation of infected cells. Philpott and Buehring (p. 933) have investigated the mechanism by which Tax proteins may induce cell transformation. They observed chromosomal damage and diminished DNA integrity in both virus-infected and tax gene-transfected cells. To ascertain which pathways of DNA repair might be inhibited, the investigators evaluated the repair of selective DNA lesions introduced by specific . . . [Full Text of this Article]

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