© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 11, 899,
June 2, 1999
© 1999 Oxford University Press
IN THIS ISSUE |
Human T-cell leukemia virus (HTLV) and bovine leukemia virus (BLV) are retroviruses that
cause hematopoietic cancers and encode a unique protein, Tax, which is involved in the
transformation of infected cells. Philpott and Buehring (p. 933) have
investigated the mechanism by which Tax proteins may induce cell transformation. They
observed chromosomal damage and diminished DNA integrity in both virus-infected and tax
gene-transfected cells. To ascertain which pathways of DNA repair might be inhibited, the
investigators evaluated the repair of selective DNA lesions introduced by specific
BRCA1 and BRCA2 Mutations in Early-Onset Breast Cancer
Prostaglandin E2 Levels in Rectal Mucosa
HPV and Risk of Cervical Lesions
Colorectal Cancer
Androgen Receptor Polymorphism and Breast Cancer Risk