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JNCI Journal of the National Cancer Institute 1999 91(10):820-822;
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 10, 820-822, May 19, 1999
© 1999 Oxford University Press

NEWS

Angiogenesis Research Is on Fast Forward

Nancy J. Nelson

While the media and the public anxiously await the start of human trials with the angiogenesis inhibitor, endostatin, scientists are busy trying to understand the basic biology behind the delicate mechanisms that cause short bursts of blood vessel growth when needed and shut them off when the job is completed.

Several presentations at the annual meeting of the American Association for Cancer Research in Philadelphia in April confirmed that angiogenesis research is not only moving forward rapidly but becoming more complex.

"We're realizing that angiogenesis is not as simple as we once thought. We previously envisioned a single growth factor inducing an endothelial cell to make blood vessels," said Lee M. Ellis, M.D., a surgical oncologist from the University of Texas M. D. Anderson Cancer Center, Houston, who chaired a mini-symposium on angiogenesis.



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