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JNCI Journal of the National Cancer Institute 1999 91(1):1; doi:10.1093/jnci/91.1.1a
© 1999 by Oxford University Press
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Journal of the National Cancer Institute, Vol. 91, No. 1, 1, January 6, 1999
© 1999 Oxford University Press

MEMORANDUM FOR: Science Writers and Editors on the Journal Press List

December 30, 1998 (EMBARGOED FOR RELEASE 4 P.M. EST January 5)

Julianne Chappell, Executive Editor, Dan Eckstein, 301-986-1891

Resistance of Breast Cancer to Tamoxifen Can Be Reversed in Animals by Antibodies to Transforming Growth Factor-ß

A new study may have identified and reversed a novel mechanism that makes some breast cancers resistant to the widely used drug tamoxifen.

Carlos L. Arteaga, M.D., of the Vanderbilt University School of Medicine, and co-authors present their findings in the January 6 issue of the Journal of the National Cancer Institute.

The authors knew from previous experiments that transforming growth factor-ß (TGF-ß ) is overproduced by some human breast cancers that are resistant to tamoxifen. Therefore, they determined in this study whether interfering with the production of TGF-ß could reduce the resistance of certain human breast cancer cells to the effects of tamoxifen.

Two human breast cancer cell lines were used in this study, one (LCC1) that produced low levels of TGF-ß and responded to tamoxifen and another (LCC2) that overproduced TGF-ß 2 and was resistant to tamoxifen. Both cell lines . . . [Full Text of this Article]

Chromosome Used to Stop Growth of Breast Cancer Cells

ß-Carotene Supplementation Produces Precancerous Lung Lesions in Ferrets


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