© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 1, 16-18,
January 6, 1999
© 1999 Oxford University Press
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Gene Imprinting: Making an Impression on Cancer Research
Restoring a normal process known as genomic imprinting may furnish researchers with a novel way of preventing and treating many cancers in the future. Imprinting involves an exquisitely small number of genes where one copy inherited from one parent is active, while the same gene from the other parent is inactive or silent. When cancer occurs, this balance is somehow perturbed.
Gene imprinting really is "gene expression dependent on parental origin,"
said Wolf Reik, M.D., head of the Developmental Genetics Program at Babraham Institute in
England. "Some genes in the genome a minority of
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