© 1999 by Oxford University Press
Journal of the National Cancer Institute, Vol. 91, No. 1, 1,
January 6, 1999
© 1999 Oxford University Press
IN THIS ISSUE |
Breast cancers can become resistant to treatment with the drug tamoxifen. Arteaga et al. (p. 46) have performed studies to uncover mechanisms that may play a role in
this resistance. By use of a tamoxifen-resistant human breast cancer cell line, LCC2, and a related
tamoxifen-sensitive line, LCC1, they showed that large amounts of transforming growth
factor-ß2 were secreted by the resistant line but not by the sensitive line. They also showed
that the growth of LCC2 tumors in nude mice could be inhibited by treatment with tamoxifen and
neutralizing antibodies against
Telomerase: Cellular Immortality and Its Reversal
Ferrets, ß-Carotene, and Tobacco Smoke
Vinorelbine, Quality of Life, and Advanced Non-Small-Cell Lung Cancer
Breast Cancer and Marital Stability
Predicting Sarcoma Aggressiveness