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JNCI Journal of the National Cancer Institute 1998 90(19):1428-1430; doi:10.1093/jnci/90.19.1428
© 1998 by Oxford University Press
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Tamoxifen Debate Hinges on Whose Risk is High Enough

Tamoxifen moved another step closer to approval for breast cancer prevention when the Oncologic Drugs Advisory Committee of the Food and Drug Administration on Sept. 2 recommended approval of its use to reduce the risk of breast cancer in women at high risk for the disease.

But questions remain about whose risk is high enough to outweigh the risk of potential side effects. So far, physicians appear cautious about prescribing tamoxifen to healthy women. And new findings heralding the preventive potential of a rival drug, raloxifene, complicate the picture.

After release of the Breast Cancer Prevention Trial results, first announced in April and published Sept. 16, showing a 49% . . . [Full Text of this Article]


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