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JNCI Journal of the National Cancer Institute 2009 101(8):539; doi:10.1093/jnci/djp088
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© Oxford University Press 2009.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

On the Origins of Multifocal Lung Cancer

Alternate theories have been proposed to explain the origin of multifocal lung cancer: 1) the separate tumors are of monoclonal origin, arising from a single transformed cell and 2) the separate tumors originate from anatomically distinct progenitor cells that undergo independent genetic alterations leading to transformation. Wang et al. (p. 560) used molecular techniques to analyze genetic alterations in tumors from patients with multifocal lung cancer and observed that separate tumors in most patients had identical genetic changes consistent with a monoclonal origin. They suggest that characterizing genetic changes in multifocal tumors might eventually prove useful . . . [Full Text of this Article]

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