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Approaches to Estimating the Risk of Breast Cancer
It is unclear whether the risk of breast cancer for postmenopausal women should be routinely estimated and then followed by risk-reducing interventions for those at high risk. Cummings et al. (p. 384) systematically reviewed prospective studies of methods to estimate breast cancer risk. Using meta-analyses, they found that breast density was strongly associated with breast cancer risk, and it improved estimates of risk with models based on risk factors. They also found that levels of estradiol and testosterone were associated with breast cancer risk. The authors also looked at the effects of tamoxifen and raloxifene for primary prevention of breast cancer, using meta-analysis, and found that
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