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Journal of the National Cancer Institute Advance Access originally published online on September 15, 2009
JNCI Journal of the National Cancer Institute 2009 101(19):1302-1304; doi:10.1093/jnci/djp340
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© Oxford University Press 2009.

NEWS

Inflammatory Breast Cancer: New Hopes and Many Hurdles

Karen Rowan

The first 150 words of the full text of this article appear below.

The field of inflammatory breast cancer (IBC) research is rife with enigmas and grim statistics. It is more aggressive and deadly than other breast cancers (see Stat Bite), and the mechanisms driving its rapid progression and metastasis remain unclear. Also perplexing is why the disease disproportionately strikes African American women and women of North African or Middle Eastern descent. Even its name needs deciphering; the typical redness and swelling of the breast seen in IBC that superficially resemble inflammation are actually due to lymph ducts that have been clogged with tumor cells.

But recent findings have begun to unlock IBC's mysteries. The search for molecular markers is revealing the genes at work in this disease, and research is turning up clues to how metastasis may unfold. With new cell lines and animal models in the works, and promising findings in several recent studies, those in the field are hopeful . . . [Full Text of this Article]

Gene Discovery

More Cell Lines?


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