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Journal of the National Cancer Institute Advance Access originally published online on June 23, 2009
JNCI Journal of the National Cancer Institute 2009 101(13):910-912; doi:10.1093/jnci/djp191
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© Oxford University Press 2009.

NEWS

Testing for Carcinogens: Shift From Animals to Automation Gathers Steam—Slowly

Charlie Schmidt

The first 150 words of the full text of this article appear below.

For more than 50 years, scientists have screened chemicals for carcinogenicity by testing them in rats and mice. But public health agencies in the U.S. are now moving toward what's been described as a major shift in toxicology: aiming to replace animal tests with automated, cell-based assays.

The U.S. Environmental Protection Agency (EPA) is the latest to go in this direction. In its Strategic Plan for Evaluating the Toxicity of Chemicals, released in March, the EPA concedes that its present screening protocols can't keep pace with the enormous backlog of untested chemicals in commerce, which now stands at about 74,000. EPA's new goal is to look for chemically induced "perturbations" to molecular pathways involved in toxicity and disease consequences such as cancer. Robert Kavlock, Ph.D., director of the agency's National Center for Computational Toxicology, predicts that with this approach, researchers could screen chemicals for safety in a matter of . . . [Full Text of this Article]

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