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JNCI Journal of the National Cancer Institute 2009 101(13):901; doi:10.1093/jnci/djp195
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© Oxford University Press 2009.

IN THIS ISSUE

The first 10% of the full text of this article appears below.

Possible Tumor Suppressor and Biomarker in Colorectal Cancer

The expression of N-Myc downstream-regulated gene 4 (NDRG4), a possible tumor suppressor gene in colorectal cancer, is frequently inactivated by promoter methylation. Melotte et al. (p. 916) examined NDRG4 expression in normal human colon mucosa and human colorectal cancer tissue and in colorectal cancer cell lines that stably overexpressed NDRG4. They then tested the potential utility of NDRG4 promoter methylation as a biomarker for early detection of colorectal cancer in stool from colorectal cancer patients and subjects without colorectal cancer. NDRG4 promoter methylation was more prevalent in colorectal cancers than in noncancerous colon mucosa. NDRG4 mRNA . . . [Full Text of this Article]

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