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Journal of the National Cancer Institute Advance Access originally published online on May 12, 2009
JNCI Journal of the National Cancer Institute 2009 101(10):700-701; doi:10.1093/jnci/djp137
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© Oxford University Press 2009.

NEWS

CANDIDATE TUMOR VIRUSES

Is a Retrovirus Implicated in Familial Prostate Cancer?

Vicki Brower

The first 150 words of the full text of this article appear below.

Three years ago, researchers discovered a retrovirus that appeared to be more common in the tumors of men with familial prostate cancer than in those with sporadic prostate cancer. Since then, the virus, XMRV, has become the focus of a growing number of studies in the U.S. and elsewhere. Not everyone agrees that XMRV is involved in familial prostate cancer, but there is little doubt that the discovery has attracted the attention of viral researchers.

That's partly because XMRV is one of a very few authentic, known human retroviruses, said Stephen Goff, Ph.D., who heads a laboratory studying retrovirus replication at Columbia University in New York. Although retroviruses have long been implicated in animal cancers, only three—human T-lymphotropic viruses 1 and 2 and human immunodeficiency virus—have been linked to cancer in humans.


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  		Stephen Goff, Ph.D.

 
"Retroviruses have had a horrible, checkered history, with lots of ‘rumor viruses’—mouse-contaminated cells mistaken . . . [Full Text of this Article]

The Questions

Indirect Mechanisms?


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