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Journal of the National Cancer Institute Advance Access originally published online on May 12, 2009
JNCI Journal of the National Cancer Institute 2009 101(10):696-697; doi:10.1093/jnci/djp097
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© The Author 2009. Published by Oxford University Press.

EDITORIALS

Women With Cervical Intraepithelial Neoplasia: Requirement for Active Long-Term Surveillance After Therapy

Edward J. Wilkinson

Affiliation of author: Department of Pathology, University of Florida College of Medicine, Gainesville, FL

Correspondence to: Edward J. Wilkinson, MD, Department of Pathology, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610-0275 (e-mail: wilkinso@pathology.ufl.edu).

The first 150 words of the full text of this article appear below.

In this issue of the Journal, Melnikow et al. (1) present a retrospective long-term follow-up analysis of 37 142 women who were treated for cervical intraepithelial neoplasia (CIN) 1, 2, and 3 from 1986 through 2000 and were under active surveillance after therapy through 2004. These women were compared with a cohort of women with no previous diagnosis of CIN who were under active surveillance.

This retrospective long-term follow-up study demonstrates that our screening methods are not as sensitive as we might hope and that high-grade CIN (ie, CIN 2 or 3 [CIN 2/3]) and/or cervical carcinoma can elude active surveillance methods. Results of this study also support evidence that active surveillance has value in identifying the majority of the high-grade CIN lesions and cervical carcinomas and that the majority of cervical carcinomas can be identified at an early stage. These data also support a recent study (. . . [Full Text of this Article]


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