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Journal of the National Cancer Institute Advance Access originally published online on December 30, 2008
JNCI Journal of the National Cancer Institute 2009 101(1):6-8; doi:10.1093/jnci/djn481
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© Oxford University Press 2008.

NEWS

From Human to Mouse and Back: 'Tumorgraft' Models Surge in Popularity

Ken Garber

The first 150 words of the full text of this article appear below.

Mouse xenograft models of cancer, understandably, have a terrible reputation. Although researchers and companies routinely use these human tumors in mice for preclinical drug testing, individual models poorly predict how drugs will act in the clinic. Retrospective reviews published by the National Cancer Institute in 2001 and the National Cancer Institute of Canada in 2003 came to the same conclusion: Drugs that work against cancer in xenograft mice rarely work in people with the same tumor, with the exception of lung and possibly ovarian cancer. "There's this mantra: ‘Xenografts don’t predict for human effects,’" said Peter Houghton, Ph.D., a cancer researcher at the St. Jude Children's Research Hospital in Memphis, Tenn.


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  		Peter Houghton, Ph.D.

 
But not all xenograft models poorly predict drug effects. In direct transfer, or "explant," xenografts, recently dubbed "tumorgrafts," tumors taken from patients are chopped into fragments slightly smaller than a pencil eraser and implanted directly . . . [Full Text of this Article]

Of Mice and Men

Power To Predict

Mining the Model


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