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Journal of the National Cancer Institute Advance Access originally published online on December 30, 2008
JNCI Journal of the National Cancer Institute 2009 101(1):4-5; doi:10.1093/jnci/djn452
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© The Author 2008. Published by Oxford University Press.

EDITORIALS

Building a Knowledge Base on Genetic Variation and Cancer Risk Through Field Synopses

Ajay Yesupriya, Marta Gwinn, Muin J. Khoury

Affiliation of authors: National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA

Correspondence to: Ajay Yesupriya, MPH, National Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Highway Mailstop K-89, Atlanta, GA 30341 (e-mail address: ayesupriya@cdc.gov).

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The number of assessed genetic associations has grown tremendously in the past few years (1), especially with the recent advent of genome-wide association studies (GWAS) (2). However, the nonreplication of findings across multiple studies remains a documented issue for human genome epidemiology, even in the GWAS era (3, 4). It has been recommended that systematic reviews including meta-analyses be conducted to assess or adjust for factors that may contribute to the nonreplication of . . . [Full Text of this Article]


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