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Journal of the National Cancer Institute Advance Access originally published online on March 25, 2008
JNCI Journal of the National Cancer Institute 2008 100(7):456-461; doi:10.1093/jnci/djn095
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© Oxford University Press 2008.

NEWS

Biomarker Developers Face Big Hurdles

Rabiya S. Tuma

The first 10% of the full text of this article appears below.

Personalized medicine is the ultimate goal of modern cancer treatment. Its success depends on the availability of tumor markers that can be used to guide treatment. Yet few clinically useful biomarkers have been validated despite decades of intense effort.

To improve the success rate, individual scientists and formal committees are working to develop methods and guidelines for biomarker development. Their work aims to improve everything from clinical trial design and issues of statistical validation to specimen collection and the quality of manuscripts reporting study results. But even with these efforts, no one expects that the changes will be quick or easy.

The Difficult Task

"It is very difficult indeed to show that something you measure in the blood or in the tumor will predict reliably the benefit of . . . [Full Text of this Article]

Improving the Development

New Guidelines


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