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Journal of the National Cancer Institute Advance Access originally published online on February 12, 2008
JNCI Journal of the National Cancer Institute 2008 100(4):232-239; doi:10.1093/jnci/djn032
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© Oxford University Press 2008.

NEWS

EMT Research Surges

Epithelial-to-Mesenchymal Transition Is Important to Metastasis, But Questions Remain

Ken Garber

The first 150 words of the full text of this article appear below.

How tumors spread and kill their hosts remains a mystery. To metastasize, cancer cells must break many fundamental rules of normal cellular behavior: They detach from neighboring cells, move freely on their own, enter the bloodstream and survive there, and finally exit into new tissue and colonize it. The whole area of metastasis has been "one of unfathomable complexity," MIT cancer researcher Robert Weinberg, Ph.D., said at the 2006 American Association for Cancer Research annual meeting.

It's especially hard to conceive how epithelial tumors—about 90% of all cancers—could ever metastasize. Epithelial cells, which line body surfaces and cavities, are tightly zipped together and largely immobile. But now a potential mechanism for metastatic spread is gaining traction: the epithelial-to-mesenchymal transition (EMT). EMT is a normal process in embryonic development in which epithelial cells transform into mesenchymal cells, the highly mobile cells that give rise to bone, muscle, connective tissue, and blood . . . [Full Text of this Article]

An Exploding Field

Persuading the Pathologists

Exploiting EMT


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