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Journal of the National Cancer Institute Advance Access originally published online on December 9, 2008
JNCI Journal of the National Cancer Institute 2008 100(24):1743-1745; doi:10.1093/jnci/djn409
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© The Author 2008. Published by Oxford University Press.

EDITORIALS

More About Second Cancers After Retinoblastoma

Anna T. Meadows, Ann M. Leahey

Affiliation of authors: The Children's Hospital of Philadelphia, Philadelphia, PA

Correspondence to: Anna T. Meadows, MD, Children's Hospital of Philadelphia, Pediatric Oncology, 3400 Civic Center Blvd, Philadelphia, PA 19104 (e-mail: meadows@email.chop.edu).

The first 10% of the full text of this article appears below.

In 1973, Strong and Knudson (1) predicted that second cancers would occur at an increased rate in survivors of retinoblastoma, that only those with the genetic form of the tumor would be at risk, and that radiation therapy (RT) would increase the risk. Beginning with a report from the Late Effects Study Group in which retinoblastoma emerged as the most common primary cancer—it occurred in 52 of 292 children with more than one malignant disease (2)—many other cohort studies have confirmed this increased risk (3–8). The genetic form of the disease includes all children with bilateral disease (although the . . . [Full Text of this Article]


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J Natl Cancer Inst 2008 100: 1741. [Extract] [Full Text] [PDF]



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T. Marees, A. C. Moll, S. M. Imhof, M. R. de Boer, P. J. Ringens, and F. E. van Leeuwen
Re: More About Second Cancers After Retinoblastoma
J Natl Cancer Inst, July 20, 2009; (2009) djp207v1.
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