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Journal of the National Cancer Institute Advance Access originally published online on November 11, 2008
JNCI Journal of the National Cancer Institute 2008 100(22):1566-1569; doi:10.1093/jnci/djn424
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© Oxford University Press 2008.

NEWS

Superhighway or Blind Alley? The Cancer Genome Atlas Releases First Results

Karyn Hede

The first 150 words of the full text of this article appear below.

Three years ago, when the National Cancer Institute proposed its monumental $1.5 billion effort to catalog the genomic changes involved in cancer, the goal was to improve the ability to diagnose, treat, and prevent cancer. Now the first results of The Cancer Genome Atlas project (TCGA) have arrived, and they reinforce the emerging realization that the more researchers investigate the genetics of cancer, the farther away new therapeutic applications seem to get. In response, some researchers say that it's time to step back and look at cancer holistically, searching not for the individual genetic mutations but instead for unifying principles that underlie the disease process.

"This idea of digging deep into the genome gives you a lot of information, and it's an important tool, but it's really only one tool," said Lynn Hlatky, Ph.D., director of the Center of Cancer Systems Biology at Tufts University in Boston. "If your goal . . . [Full Text of this Article]

Holistic Cancer Systems

Targeting the Cancer State


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