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Journal of the National Cancer Institute Advance Access originally published online on November 11, 2008
JNCI Journal of the National Cancer Institute 2008 100(22):1564-1565; doi:10.1093/jnci/djn381
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Published by Oxford University Press 2008.

EDITORIALS

Defining a Candidate Lung Cancer Gene

Frederic J. Kaye

Affiliation of author: Genetics Br, NCI, NIH and National Naval Medical Center, NCI-Navy Oncology, Bethesda, MD

Correspondence to: Frederic J. Kaye, MD, Genetics Br, NCI, NIH and National Naval Medical Center, NCI-Navy Oncology/Bldg 8, Rm 5101, 8901 Wisconsin Ave, Bethesda, MD 20889 (e-mail: kayef@mail.nih.gov).

The first 10% of the full text of this article appears below.

In this issue of the Journal, Yuan et al. (1) tested 50 uncharacterized genes that their laboratory had previously shown to be differentially expressed in squamous cell lung tumors as compared with normal bronchial epithelial cells (2–5) for foci formation following transfection of each gene into NIH3T3 cells using antibiotic selection. They identified one gene with foci formation, designated OLC1, and subsequently demonstrated elevated levels of OLC1 by immunoblot analysis in four lung tumor cell lines as compared with several immortalized lung lines. In addition, the authors performed immunohistochemistry (IHC) on 537 primary archival lung cancer samples embedded on tissue arrays . . . [Full Text of this Article]


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