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Journal of the National Cancer Institute Advance Access originally published online on October 28, 2008
JNCI Journal of the National Cancer Institute 2008 100(21):1496-1498; doi:10.1093/jnci/djn401
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© Oxford University Press 2008.

NEWS

Proton Therapy Use Incites Debate Over Clinical Trials

Karen Rowan

The first 150 words of the full text of this article appear below.

This is part of an occasional series that recalls some of the stories reported 10 years ago in the News section of the Journal.

Proton therapy is going through a period of enormous growth, with five centers now operational in the U.S. and seven more planned to open over the next 4 years. Compared with conventional radiation, which uses photons, proton treatments can, at least in theory, offer patients fewer side effects and a decreased chance of developing secondary cancers from radiation. But as this nascent field grows, a debate has arisen over whether randomized clinical trials comparing proton therapy with photon radiation are needed to clearly demonstrate proton therapy's benefits—and whether now is the appropriate time for such trials to begin.

Proton therapy differs from conventional radiation in several ways. In conventional radiation treatments, a linear accelerator fires photons at a tumor. These photons, which are delivered as high-energy . . . [Full Text of this Article]

Phase III Trials Debated

Future of Proton Therapy


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