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Journal of the National Cancer Institute Advance Access originally published online on September 9, 2008
JNCI Journal of the National Cancer Institute 2008 100(18):1271-1273; doi:10.1093/jnci/djn306
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Published by Oxford University Press 2008.

EDITORIALS

Progress in the Curative Treatment of Childhood Hematologic Malignancies

Alan S. Wayne, Gregory H. Reaman, Lee J. Helman

Affiliations of authors: Hematologic Diseases Section, Pediatric Oncology Branch (ASW), Center for Cancer Research (LJH), National Cancer Institute, National Institutes of Health, Bethesda, MD; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences and Children's Oncology Group, COG Chair's Office, Bethesda, MD (GHR)

Correspondence to: Alan S. Wayne, MD, Hematologic Diseases Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 10, Room 1W-3750, MSC 1104, 9000 Rockville Pike, Bethesda, MD 20892-1104 (e-mail: waynea@mail.nih.gov).

The first 10% of the full text of this article appears below.

Hematologic malignancies account for approximately 40% of childhood cancer (1). Progress in the curative treatment of this group of cancers is one of the great medical success stories of the 20th century. There have been improvements in outcome for all major subtypes of pediatric leukemias and lymphomas, the most dramatic of which has been in acute lymphoblastic leukemia (ALL), the commonest childhood malignancy. At the time that the National Cancer Act of 1971 (Public Law 92-218) made the "conquest of cancer a national crusade" (President Richard M. Nixon, December 23, 1971) fewer than 10% of children with ALL survived for 10 years after diagnosis. Survival rates for . . . [Full Text of this Article]


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