Journal of the National Cancer Institute Advance Access originally published online on August 26, 2008
JNCI Journal of the National Cancer Institute 2008 100(17):1265-1266; doi:10.1093/jnci/djn235
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© The Author 2008. Published by Oxford University Press.
CORRESPONDENCE |
Response: Re: Intensity-Modulated Radiation Therapy Dose Prescription, Recording, and Delivery: Patterns of Variability Among Institutions and Treatment Planning Systems
Affiliations of authors: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (IJD, EG); Morristown Memorial Hospital, Morristown, NJ (CWC); Kennedy Health System, Sewell, NJ (KLC); Ochsner Clinic Foundation, New Orleans, LA (RKM); Reid Hospital & Health Care Service, Richmond, IN (SPS)
Correspondence to: Indra J. Das, Radiation Oncology, University of Pennsylvania, 2 Donner Bldg, 3400 Spruce St, Philadelphia, PA 19104 (e-mail: das@xrt.upenn.edu).
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We thank Olch and Lavey, Deye et al., Galvin et al., and Chien et al. for their interest in our paper (1) and their willingness to be provoked into a response. The discussion of some of the issues raised is healthy, and it is worthwhile to challenge the assumptions inherent in this topic. We agree that both clinical significance and achievability should be carefully considered in developing the dose–volume specifications used in clinical trials, and that