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Journal of the National Cancer Institute Advance Access originally published online on May 27, 2008
JNCI Journal of the National Cancer Institute 2008 100(11):766-767; doi:10.1093/jnci/djn186
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© Oxford University Press 2008.

NEWS

RNA Interference Provides New Approach for Finding Cancer Genes

Brian Vastag

The first 10% of the full text of this article appears below.

By leveraging a cell's built-in ability to squelch individual genes, a pair of scientists has invented a quick and relatively inexpensive method for finding weaknesses in cancer cells. The approach uses a cell culture system that screens thousands of genes simultaneously for their effects on the growth and survival of tumor cells.

In two reports in Science this February, Gregory Hannon, Ph.D., and Stephen Elledge, Ph.D., describe the system and identify dozens of potential new gene targets for fighting colon and breast cancer. The researchers hope that their approach will lead to new drugs that selectively kill cancer cells.

"We’re finding all kinds of potential new targets in our gene lists that are specific for killing cancer . . . [Full Text of this Article]

Barcoding RNA

Complementary Approaches


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