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Journal of the National Cancer Institute Advance Access originally published online on May 13, 2008
JNCI Journal of the National Cancer Institute 2008 100(10):694-695; doi:10.1093/jnci/djn168
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© Oxford University Press 2008.

NEWS

Lapatinib Study Supports Cancer Stem Cell Hypothesis, Encourages Industry Research

Charles Schmidt

The first 150 words of the full text of this article appear below.

Last year, scientists reported for the first time that the drug lapatinib (Tykerb) can cause complete tumor regression, possibly by killing cancer stem cells. Presented at the San Antonio Breast Cancer Conference on December 17, the findings showed that among 40 women with HER2-positive breast cancer who took lapatinib for 6 weeks—followed by 6 weeks of standard chemotherapy and trastuzumab—63% experienced a "pathologically complete response," meaning that there was no evidence of any remaining tumor. Jenny Chang, M.D., an associate professor at the Baylor College of Medicine in Houston, who led the study, said that 10%–20% of the women would probably have achieved a pathologically complete response with chemotherapy alone; this figure rises to 30% with chemotherapy and trastuzumab combined. "So, these are very exciting findings," she said. "We know that women with a pathologically complete response have the least likelihood of a recurrence." Chang's study is now undergoing . . . [Full Text of this Article]


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