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Journal of the National Cancer Institute Advance Access originally published online on May 13, 2008
JNCI Journal of the National Cancer Institute 2008 100(10):688-689; doi:10.1093/jnci/djn149
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© The Author 2008. Published by Oxford University Press.

EDITORIAL

FDG-PET Staging of Head and Neck Cancer—Can Improved Imaging Lead to Improved Treatment?

David L. Schwartz, Homer A. Macapinlac, Randal S. Weber

Affiliation of authors: Departments of Radiation Oncology (DLS), Experimental Diagnostic Imaging (DLS), Nuclear Medicine (HAM), and Head and Neck Surgery (RSW), The University of Texas M. D. Anderson Cancer Center, Houston, TX

Correspondence to: David L. Schwartz, MD, Department of Radiation Oncology, Unit 97, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (e-mail: docdls@mdanderson.org).

The first 10% of the full text of this article appears below.

Head and neck cancer levies a steep toll from those it afflicts, particularly through treatment-associated toxicity. Tangible improvements in tissue sparing, supportive care, and recuperative strategies have been made. Nonetheless, combined modality strategies favored for locally advanced disease continue to demand substantial cosmetic, nutritional, and functional sacrifices in exchange for improved survival. The way to best limit such morbidity is to tailor treatment to the exact location and severity of disease. If the tumor can be reliably localized, bystander tissues appropriately excluded from operative and radiation fields, and lower risk patients safely triaged away from cytotoxic chemotherapy, then the up-front and longitudinal costs of head and neck cancer treatment can be tangibly reduced without conceding efficacy.

In this spirit, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging has gradually become part of the routine management of head and neck cancer . . . [Full Text of this Article]


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