© 1988 by Oxford University Press
Journal of the National Cancer Institute, Vol. 80, No. 3, 200-204,
April 6, 1988
© 1988 Oxford University Press
Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential2
3Laboratory of Pathology, Division of Cancer Biology and Diagnosis, National Cancer Institute Bethesda, MD 20892.
4Preclinical Screening Section, Biological Response Modifiers Program, National Cancer Institute, NCI-Frederick Cancer Research Facility Frederick, MD.
We describe a gene, NM23, that is associated with the tumor metastatic process. NM23 RNA levels were highest in cells and tumors of relatively low metastatic potential in two experimental systems: (1) murine K-1735 melanoma cell lines, in which the gene was identifiede, and (2) N-nitroso-N-methylurea-induced rat mammary earcinomas. NM23 RNA levels did not correlate with cell sensitivity to host immunological responses and may, therefore, be associated with intrinsle aggressiveness. The predicted carboxy-terminal protein seaquence encoded by the pNM23 cDNA clone is nove compared with Genebank animal, bacterial, and viral sequences.[J Natl Cancer Inst 1988;80:200–204]
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Online Perspective about this Classic Article
- PERSPECTIVES ON CLASSIC ARTICLES: Metastasis Suppressor Genes
- Patricia S. Steeg
J Natl Cancer Inst 2004 96: E4.[Extract] [Full Text]
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