© The Author 2006. Published by Oxford University Press.
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Human Papillomavirus Infection and Incidence of Squamous Cell and Basal Cell Carcinomas of the Skin
Affiliations of authors: Department of Community and Family Medicine, Center for Environmental Health Sciences, and the Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, NH (MRK, TAS, AA, JRR, LAM); Department of Environmental Health, Harvard School of Public Health, Boston, MA (HHN); Division of Genome Modifications and Carcinogenesis, Research Program Infection and Cancer, German Cancer Research Center, Heidelberg, Germany (PS, TW, MP); Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada (TAS); Queensland Institute of Medical Research, Brisbane, Australia (ACG); Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands (JNBB); Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH (AP); Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH (SS)
Correspondence to: Margaret R. Karagas, PhD, Dartmouth Medical School, 7927 Rubin, One Medical Center Drive, Lebanon, NH 03756 (e-mail: margaret.karagas{at}dartmouth.edu).
Background: Although infection with human papillomaviruses (HPVs) is a major risk factor for several epithelial cancers, an etiologic relationship between HPV and keratinocyte cancers, such as squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), remains unclear. Methods: In a population-based case–control study of 252 SCC case patients, 525 BCC case patients, and 461 control subjects, we used multiplex serology to detect antibodies in plasma samples against 16 HPV types from phylogenetic genera alpha, beta, and mu. Multiplex serology is a new method that is based on fluorescent bead technology and allows simultaneous detection of antibodies against up to 100 different in situ affinity-purified recombinant HPV proteins. Data on sun sensitivity, outdoor exposure, and other risk factors for keratinocyte cancers were collected through personal interviews. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated via unconditional logistic regression models. Results: Overall, we detected HPV antibodies more frequently in SCC patients than in control subjects (OR = 1.6, 95% CI = 1.2 to 2.3), but we found no difference in HPV seropositivity between BCC case patients and control subjects (OR = 0.8, 95% CI = 0.6 to 1.1). Among HPV types, seropositivity to HPV types in genus beta (OR = 1.5, 95% CI = 1.0 to 2.1), particularly HPV 5 (OR = 1.8, 95% CI = 1.0 to 3.1), was associated with SCC risk. Individuals with tumors on chronically sun exposed sites were more likely to be seropositive for beta HPV types than individuals with SCC at other anatomic sites. The highest SCC risk was associated with positivity for multiple HPV types and, among individuals seropositive for HPV beta, a tendency to sunburn; however, the associations had limited statistical precision. Conclusions: Our findings support a role for HPV types from the genus beta in the pathogenesis of SCC.
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Correspondence about this Article
- Re: Human Papillomavirus Infection and Incidence of Squamous Cell and Basal Cell Carcinomas of the Skin
- Lisa Hall, Linda Struijk, Rachel E. Neale, and Mariet C. W. Feltkamp
J Natl Cancer Inst 2006 98: 1425-1426.[Extract] [Full Text] [PDF]
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