Skip Navigation

JNCI Journal of the National Cancer Institute 2006 98(4):285-288; doi:10.1093/jnci/djj054
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (53)
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Menin, C.
Right arrow Articles by Bertorelle, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Menin, C.
Right arrow Articles by Bertorelle, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press.

BRIEF COMMUNICATION

Association Between MDM2–SNP309 and Age at Colorectal Cancer Diagnosis According to p53 Mutation Status

Chiara Menin, Maria Chiara Scaini, Gian Luca De Salvo, Martina Biscuola, Monica Quaggio, Giovanni Esposito, Claudio Belluco, Marco Montagna, Simona Agata, Emma D'Andrea, Donato Nitti, Alberto Amadori, Roberta Bertorelle

Affilations of authors: IST-Genova (CM, MM) c/o Azienda Ospedaliera di Padova and Istituto Oncologico Veneto, Padova, Italy (MB, GE, RB); Clinical Trials and Biostatistical Unit, Istituto Oncologico Veneto, Padova, Italy (GLDS); Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy (MCS, MQ, CB, SA, EDA, DN, AA)

Correspondence to: Chiara Menin, PhD, Dipartimento di Scienze Oncologiche e Chirurgiche, Sezione di Oncologia, via Gattamelata 64, 35128 Padova, Italy (e-mail: chiara.menin{at}unipd.it).

A single-nucleotide polymorphism (SNP) in the promoter of the MDM2 gene, SNP309 (a T->G change), was recently implicated in the early onset of cancer in individuals with Li-Fraumeni syndrome and of sporadic soft-tissue sarcoma. SNP309 induces an increase in the level of Mdm2 protein, which causes attenuation of the p53 pathway. To investigate the effect of this polymorphism in colorectal cancer pathogenesis, we genotyped 153 colorectal cancer patients who were randomly selected from among 330 consecutive patients stratified according to p53 mutation status and age at diagnosis, for alleles of MDM2–SNP309. Among the 77 patients with p53 wild-type tumors, the median age at colorectal cancer diagnosis was 71.5 years for patients with the T/T genotype and 61.0 years for patients with SNP309 (T/G or G/G genotype) (estimated difference between medians [Hodges–Lehmann method] = 8.0 years, 95% confidence interval = 1.0 to 16.0 years; P = .03 [two-sided Wilcoxon rank sum test]). Our data indicate that MDM2–SNP309 is a modifier of the age at colorectal cancer onset for patients whose tumors have a wild-type p53 gene.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
L. F. Grochola, A. Vazquez, E. E. Bond, P. Wurl, H. Taubert, T. H. Muller, A. J. Levine, and G. L. Bond
Recent Natural Selection Identifies a Genetic Variant in a Regulatory Subunit of Protein Phosphatase 2A that Associates with Altered Cancer Risk and Survival
Clin. Cancer Res., October 1, 2009; 15(19): 6301 - 6308.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. S. Atwal, T. Kirchhoff, E. E. Bond, M. Montagna, C. Menin, R. Bertorelle, M. C. Scaini, F. Bartel, A. Bohnke, C. Pempe, et al.
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene
PNAS, June 23, 2009; 106(25): 10236 - 10241.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. F. Firoz, M. Warycha, J. Zakrzewski, D. Pollens, G. Wang, R. Shapiro, R. Berman, A. Pavlick, P. Manga, H. Ostrer, et al.
Association of MDM2 SNP309, Age of Onset, and Gender in Cutaneous Melanoma
Clin. Cancer Res., April 1, 2009; 15(7): 2573 - 2580.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Terrin, E. Rampazzo, S. Pucciarelli, M. Agostini, R. Bertorelle, G. Esposito, P. DelBianco, D. Nitti, and A. De Rossi
Relationship Between Tumor and Plasma Levels of hTERT mRNA in Patients with Colorectal Cancer: Implications for Monitoring of Neoplastic Disease
Clin. Cancer Res., November 15, 2008; 14(22): 7444 - 7451.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
H. Taubert, F. Bartel, T. Greither, M. Bache, M. Kappler, T. Kohler, A. Bohnke, C. Lautenschlager, H. Schmidt, H.-J. Holzhausen, et al.
Association of HDM2 Transcript Levels with Age of Onset and Prognosis in Soft Tissue Sarcomas
Mol. Cancer Res., October 1, 2008; 6(10): 1575 - 1581.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Cattelani, R. Defferrari, S. Marsilio, R. Bussolari, O. Candini, F. Corradini, G. Ferrari-Amorotti, C. Guerzoni, L. Pecorari, C. Menin, et al.
Impact of a Single Nucleotide Polymorphism in the MDM2 Gene on Neuroblastoma Development and Aggressiveness: Results of a Pilot Study on 239 Patients
Clin. Cancer Res., June 1, 2008; 14(11): 3248 - 3253.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
I. Gryshchenko, S. Hofbauer, M. Stoecher, P. T. Daniel, M. Steurer, A. Gaiger, K. Eigenberger, R. Greil, and I. Tinhofer
MDM2 SNP309 Is Associated With Poor Outcome in B-Cell Chronic Lymphocytic Leukemia
J. Clin. Oncol., May 10, 2008; 26(14): 2252 - 2257.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
K. Terry, M. McGrath, I-M. Lee, J. Buring, and I. De Vivo
MDM2 SNP309 Is Associated with Endometrial Cancer Risk
Cancer Epidemiol. Biomarkers Prev., April 1, 2008; 17(4): 983 - 986.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
A. Forslund, Z. Zeng, L.-X. Qin, S. Rosenberg, M. Ndubuisi, H. Pincas, W. Gerald, D. A. Notterman, F. Barany, and P. B. Paty
MDM2 Gene Amplification Is Correlated to Tumor Progression but not to the Presence of SNP309 or TP53 Mutational Status in Primary Colorectal Cancers
Mol. Cancer Res., February 1, 2008; 6(2): 205 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Bartel, J. Jung, A. Bohnke, E. Gradhand, K. Zeng, C. Thomssen, and S. Hauptmann
Both Germ Line and Somatic Genetics of the p53 Pathway Affect Ovarian Cancer Incidence and Survival
Clin. Cancer Res., January 1, 2008; 14(1): 89 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
Z. Hu, G. Jin, L. Wang, F. Chen, X. Wang, and H. Shen
MDM2 Promoter Polymorphism SNP309 Contributes to Tumor Susceptibility: Evidence from 21 Case-Control Studies
Cancer Epidemiol. Biomarkers Prev., December 1, 2007; 16(12): 2717 - 2723.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Wilkening, J. L. Bermejo, and K. Hemminki
MDM2 SNP309 and cancer risk: a combined analysis
Carcinogenesis, November 1, 2007; 28(11): 2262 - 2267.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. K. Schmidt, S. Reincke, A. Broeks, L. M. Braaf, F. B.L. Hogervorst, R. A.E.M. Tollenaar, N. Johnson, O. Fletcher, J. Peto, J. Tommiska, et al.
Do MDM2 SNP309 and TP53 R72P Interact in Breast Cancer Susceptibility? A Large Pooled Series from the Breast Cancer Association Consortium
Cancer Res., October 1, 2007; 67(19): 9584 - 9590.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
P. Rajaraman, S. S. Wang, N. Rothman, M. M. Brown, P. M. Black, H. A. Fine, J. S. Loeffler, R. G. Selker, W. R. Shapiro, S. J. Chanock, et al.
Polymorphisms in Apoptosis and Cell Cycle Control Genes and Risk of Brain Tumors in Adults
Cancer Epidemiol. Biomarkers Prev., August 1, 2007; 16(8): 1655 - 1661.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Hirata, Y. Hinoda, N. Kikuno, K. Kawamoto, Y. Suehiro, Y. Tanaka, and R. Dahiya
MDM2 SNP309 Polymorphism as Risk Factor for Susceptibility and Poor Prognosis in Renal Cell Carcinoma
Clin. Cancer Res., July 15, 2007; 13(14): 4123 - 4129.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
M. Sanchez-Carbayo, N. D. Socci, T. Kirchoff, N. Erill, K. Offit, B. H. Bochner, and C. Cordon-Cardo
A Polymorphism in HDM2 (SNP309) Associates with Early Onset in Superficial Tumors, TP53 Mutations, and Poor Outcome in Invasive Bladder Cancer
Clin. Cancer Res., June 1, 2007; 13(11): 3215 - 3220.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
W. Hu, Z. Feng, L. Ma, J. Wagner, J. J. Rice, G. Stolovitzky, and A. J. Levine
A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells
Cancer Res., March 15, 2007; 67(6): 2757 - 2765.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. S. Atwal, G. L. Bond, S. Metsuyanim, M. Papa, E. Friedman, T. Distelman-Menachem, E. Ben Asher, D. Lancet, D. A. Ross, J. Sninsky, et al.
Haplotype structure and selection of the MDM2 oncogene in humans
PNAS, March 13, 2007; 104(11): 4524 - 4529.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
U. Tabori, S. Nanda, H. Druker, J. Lees, and D. Malkin
Younger Age of Cancer Initiation Is Associated with Shorter Telomere Length in Li-Fraumeni Syndrome
Cancer Res., February 15, 2007; 67(4): 1415 - 1418.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
H. Alazzouzi, G. Suriano, A. Guerra, A. Plaja, E. Espin, M. Armengol, P. Alhopuro, S. Velho, Y. Shinomura, J. J. Gonzalez-Aguilera, et al.
Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells
J. Med. Genet., January 1, 2007; 44(1): 75 - 80.
[Abstract] [Full Text] [PDF]

Home page
 J. Med. Genet.Home page
G. L Bond, C. Menin, R. Bertorelle, P. Alhopuro, L. A Aaltonen, and A. J Levine
MDM2 SNP309 accelerates colorectal tumour formation in women
J. Med. Genet., December 1, 2006; 43(12): 950 - 952.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. R. Pine, L. E. Mechanic, E. D. Bowman, J. A. Welsh, S. C. Chanock, P. G. Shields, and C. C. Harris
MDM2 SNP309 and SNP354 Are Not Associated with Lung Cancer Risk.
Cancer Epidemiol. Biomarkers Prev., August 1, 2006; 15(8): 1559 - 1561.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
B. J. Boersma, T. M. Howe, J. E. Goodman, H. G. Yfantis, D. H. Lee, S. J. Chanock, and S. Ambs
Association of Breast Cancer Outcome With Status of p53 and MDM2 SNP309.
J Natl Cancer Inst, July 5, 2006; 98(13): 911 - 919.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
G. L. Bond, K. M. Hirshfield, T. Kirchhoff, G. Alexe, E. E. Bond, H. Robins, F. Bartel, H. Taubert, P. Wuerl, W. Hait, et al.
MDM2 SNP309 Accelerates Tumor Formation in a Gender-Specific and Hormone-Dependent Manner.
Cancer Res., May 15, 2006; 66(10): 5104 - 5110.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.